<1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one

Base Information

• Chemical Name: <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one
• CAS No.: 143288-91-9
• Molecular Formula: C₂₀H₂₀INO₃
• Molecular Weight: 449.288

Synonyms:<1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one

Chemical Property of <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one

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Technology Process of <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one

There total 1 articles about <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

<3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone (101977-78-0) → <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one (143288-91-9) + <1S-(1α,2α,4α,5β,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one (143288-92-0)

Guidance literature:

With N-iodo-succinimide; In dichloromethane; a) 0 deg C, 2 h, b) to room temperature, 24 h, c) 24 h;

DOI:10.1021/jo00047a020

Reference yield: 40.0%

<1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one (143288-91-9) → <1S-(1α,2α,4β,6α)>-7-(p-methoxyphenyl)-2-methyl-4-phenyl-3-oxa-7-azabicyclo<4.2.0>octan-8-one (143288-95-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; at 70 ℃; for 0.333333h;

DOI:10.1021/jo00047a020

upstream raw materials:

<3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone

Downstream raw materials:

<1S-(1α,2α,4β,6α)>-7-(p-methoxyphenyl)-2-methyl-4-phenyl-3-oxa-7-azabicyclo<4.2.0>octan-8-one

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