101977-78-0

Basic information

• Product Name: <3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone
• Synonyms: <3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone
• CAS NO: 101977-78-0
• Molecular Weight: 323.392
• Mol File: 101977-78-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: <3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: <3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone(101977-78-0)
• EPA Substance Registry System: <3S,4S(E)>-3-<1(R)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone(101977-78-0)

Safety Data

• Hazardous Substances Data: 101977-78-0(Hazardous Substances Data)

Upstream product

• 101977-77-9 <3S,4S(E)>-3-<1(S)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone 
• 143288-86-2 Formic acid (S)-1-[(3S,4S)-1-(4-methoxy-phenyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-ethyl ester 
• 115939-19-0 (3S,4S)-1-p-methoxyphenyl-3-<(R)-1-nitroxyethyl>-4-styrylazetidin-2-one 
• 56816-01-4 ethyl (S)-3-hydroxybutyrate 
• 80542-40-1 N-cinnamylidene-p-anisidine 
• 5405-41-4 ethyl 3-hydroxybutyrate 
• 88315-63-3 (E)-4-methoxy-N-((E)-3-phenylallylidene)aniline 
• 15286-52-9 N-(4-Methoxyphenyl)-3-phenylpropenaldimine 

Downstream Products

• 143288-94-2 <1S-(1α,2α,4β,5α,6α)>-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-5-(phenylselenenyl)-7-azabicyclo<4.2.0>octan-8-one 
• 143288-93-1 <1S-(1α,2α,4α,5β,6α)>-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-5-(phenylselenenyl)-7-azabicyclo<4.2.0>octan-8-one 
• 143288-95-3 <1S-(1α,2α,4β,6α)>-7-(p-methoxyphenyl)-2-methyl-4-phenyl-3-oxa-7-azabicyclo<4.2.0>octan-8-one 
• 143288-91-9 <1S-(1α,2α,4β,5α,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one 
• 143288-92-0 <1S-(1α,2α,4α,5β,6α)>-5-iodo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one 
• 143288-89-5 <1S-(1α,2α,4β,5α,6α)>-5-bromo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one 
• 143288-90-8 <1S-(1α,2α,4α,5β,6α)>-5-bromo-7-(p-methoxyphenyl)-2-methyl-3-oxa-4-phenyl-7-azabicyclo<4.2.0>octan-8-one 
• 143288-96-4 <1S-(1α,2α,4α,6α)>-7-(p-methoxyphenyl)-2-methyl-4-phenyl-3-oxa-7-azabicyclo<4.2.0>octan-8-one 
• 115133-15-8 (1S,2S,4R,6S)-4-methoxy-2-methyl-7-(oxo(phenylmethoxy)acetyl)-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 123493-06-1 (2S,3R,4S,6R)-methyl-4-(benzoylamino)-tetrahydro-6-methoxy-2-methyl-2H-pyran-3-carboxylate 
• 123493-07-2 (2S,3R,4S,6R)-4-(benzoylamino)-tetrahydro-6-methoxy-2-methyl-2-pyran-3-carboxylic acid 
• 115133-12-5 (1S,2S,4R,6S)-7-benzoyl-4-methoxy-2-methyl-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 115133-11-4 (1S,2S,4R,6S)-4-methoxy-7-(4-methoxyphenyl)-2-methyl-3-oxa-7-azabicyclo(4.2.0)octan-8-one 
• 115133-10-3 (3S,4S)-3-((S)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-((E)-2-methoxy-vinyl)-azetidin-2-one 

Relevant articles and documents

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Stereospecific Synthesis of a Chiral Intermediate for the Preparation of Thienamycin, Penems, and Carbapenems: Use of the Nitro Group as a Hydroxy Protecting Group

A total stereo- and enantio-controlled synthesis of (3S,4R)-4-acetoxy-3-azetidin-2-one (1) from ethyl (S)-3-hydroxybutyrate is reported.A simple method of inversion and concomitant protection of the hydroxy function in the side chain i

3-(1'-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and N-arylaldimines

Dianion imine addition, cyclisation reaction between ethyl-3-hydroxybutyrate and the aldimines generates β-lactams with the hydroxyethyl side chain of thienamycin and related β-lactam antibiotics in place. The effects of the N-arylaldimine and the reactio