N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Base Information

• Chemical Name: N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine
• CAS No.: 1276113-10-0
• Molecular Formula: C₃₇H₅₁N₅O₇Si₂
• Molecular Weight: 734.012
• Mol file: 1276113-10-0.mol

Synonyms:N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Chemical Property of N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

There total 7 articles about N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1,3,3-tetraisopropyldisiloxane (18043-71-5) → N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine (1276113-10-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 3 h / 20 °C

2: dmap / acetonitrile / 20 °C

3: 2,2'-azobis(isobutyronitrile) / benzene / 50 h / 40 - 80 °C

4: pyridine / 5 h / 20 °C

5: osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 24 h / 0 - 4 °C

With pyridine; dmap; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); potassium carbonate; potassium hexacyanoferrate(III); In water; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1002/ejoc.201001448

Reference yield:

C37H49N5O5Si2 → N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine (1276113-10-0)

Guidance literature:

With osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 - 4 ℃; for 24h;

DOI:10.1002/ejoc.201001448

Reference yield:

2'-deoxy-2'-α-C-styryl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine → N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine (1276113-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 5 h / 20 °C

2: osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 24 h / 0 - 4 °C

With pyridine; osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol;

DOI:10.1002/ejoc.201001448

upstream raw materials:

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

1,1,3,3-tetraisopropyldisiloxane

2'-O-<(phenoxythio)carbonyl>-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine

benzoyl chloride

Downstream raw materials:

N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine