N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Base Information

Chemical Name:N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine
CAS No.:1276113-12-2
Molecular Formula:C₃₀H₄₅N₅O₆Si₂
Molecular Weight:627.888
Hs Code.:

Synonyms:N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

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Chemical Property of N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

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Technology Process of N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

There total 8 articles about N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1276113-10-0
N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

: 1276113-12-2
N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Guidance literature:: N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine; With sodium periodate; In 1,4-dioxane; water; at 0 - 20 ℃; for 8h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.201001448

Reference yield:

: 18043-71-5
1,1,3,3-tetraisopropyldisiloxane

: 1276113-12-2
N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 3 h / 20 °C

2.1: dmap / acetonitrile / 20 °C

3.1: 2,2'-azobis(isobutyronitrile) / benzene / 50 h / 40 - 80 °C

4.1: pyridine / 5 h / 20 °C

5.1: osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 24 h / 0 - 4 °C

6.1: sodium periodate / 1,4-dioxane; water / 8 h / 0 - 20 °C

6.2: 0.5 h / 20 °C

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); potassium carbonate; potassium hexacyanoferrate(III); In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1002/ejoc.201001448

Reference yield:

: 2'-deoxy-2'-α-C-styryl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

: 1276113-12-2
N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 5 h / 20 °C

2.1: osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 24 h / 0 - 4 °C

3.1: sodium periodate / 1,4-dioxane; water / 8 h / 0 - 20 °C

3.2: 0.5 h / 20 °C

With pyridine; sodium periodate; osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III); In 1,4-dioxane; water; tert-butyl alcohol;
DOI:10.1002/ejoc.201001448