(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Base Information

Chemical Name:(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane
CAS No.:246518-25-2
Molecular Formula:C₃₄H₃₄O₃
Molecular Weight:490.642
Hs Code.:

Synonyms:(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Suppliers and Price of (1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

There total 7 articles about (1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 14470-28-1
mono-4-methoxytrityl chloride

: 246518-24-1
(1R,3S)-3-(benzyloxymethyl)-4-methylenecyclopentanol

: 246518-25-2
(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 72h; Heating;
DOI:10.1016/S0040-4020(99)00591-8

Reference yield:

: 100-39-0
benzyl bromide

: 246518-25-2
(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutylammonium hydrogen sulfate; Et₃N; NaOH / CH₂Cl₂; H₂O / 40 h / Heating

2: 5.58 g / p-TsOH; H₂O / dioxane / 1.3 h / 70 °C

3: 81 percent / Me₄NBH(OAc)3; AcOH / acetone; acetonitrile / 48 h / 20 °C

4: 91 percent / ICH₂CH₂I; PPh₃ / tetrahydrofuran / 144 h

5: 76 percent / DBU / toluene / 18 h / 95 °C

6: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / Heating

With dmap; sodium hydroxide; 1,2-Diiodoethane; water; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; toluene; acetonitrile; 1: Etherification / 2: Hydrolysis / 3: Reduction / 4: Iodination / 5: Elimination / 6: Etherification;
DOI:10.1016/S0040-4020(99)00591-8

Reference yield:

: 246518-20-7
(3S,4S)-bis(hydroxymethyl)cyclopentanone ethylene glycol ketal

: 246518-25-2
(1R,3S)-3-(benzyloxymethyl)-1-(4-methoxyphenyldiphenylmethoxy)-4-methylenecyclopentane

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutylammonium hydrogen sulfate; Et₃N; NaOH / CH₂Cl₂; H₂O / 40 h / Heating

2: 5.58 g / p-TsOH; H₂O / dioxane / 1.3 h / 70 °C

3: 81 percent / Me₄NBH(OAc)3; AcOH / acetone; acetonitrile / 48 h / 20 °C

4: 91 percent / ICH₂CH₂I; PPh₃ / tetrahydrofuran / 144 h

5: 76 percent / DBU / toluene / 18 h / 95 °C

6: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 72 h / Heating

With dmap; sodium hydroxide; 1,2-Diiodoethane; water; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; toluene; acetonitrile; 1: Etherification / 2: Hydrolysis / 3: Reduction / 4: Iodination / 5: Elimination / 6: Etherification;
DOI:10.1016/S0040-4020(99)00591-8