4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate
CAS No.:1316228-88-2
Molecular Formula:C₁₄H₁₃F₃O₆S
Molecular Weight:366.315
Hs Code.:

Synonyms:4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

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Chemical Property of 4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

There total 3 articles about 4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1236161-55-9
3-(2-(benzyloxy)ethyl)-4-hydroxyfuran-2(5H)-one

: 1316228-88-2
4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201100491

Reference yield:

: 145436-98-2
4-Hydroxy-3-[(phenylmethoxy)acetyl]-2(5H)-furanone

: 1316228-88-2
4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride / acetic acid / 10 - 25 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid;
DOI:10.1002/ejoc.201100491

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1316228-88-2
4-(2-(benzyloxy)ethyl)-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 25 °C / Inert atmosphere

2: sodium cyanoborohydride / acetic acid / 10 - 25 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With dmap; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetic acid; 1: Fries rearrangement;
DOI:10.1002/ejoc.201100491