145436-98-2Relevant academic research and scientific papers
A synthetic route to α-substituted butenolides: Enantioselective synthesis of (+)-ancepsenolide
Ghobril, Cynthia,Kister, Jeremy,Baati, Rachid
supporting information; experimental part, p. 3416 - 3419 (2011/09/13)
A variety of α-substituted butenolides was efficiently synthesized starting from commercially available tetronic acid and carboxylic acids in four steps. The effectiveness of this approach is illustrated in the short synthesis of one of the first butenoli
TETRONIC AND THIOTETRONIC ACID DERIVATIVES AS PHOSPHOLIPASE A2 INHIBITORS
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, (2008/06/13)
There are disclosed compounds of the formula: wherein X is ?CH2R; R is and further when Y=S, R may also be ?(CH2)eCH3; Y is ?O?or ?S?; R1 and R2 are each, independently, hydrogen or lower alkyl; R3 is indolyl, furyl, phenyl or phenyl optionally mono- or disubstituted independently by alkyl of 1-7 carbon atoms, ?C(CH3)3, ?C(CH3)2CH2C(CH3), ?C(CH3)2CH2CH3, haloloweralkyl, perfluoroalkyl, lower alkoxy, aryl alkoxy, halo or nitro; R4 and R5 are, independently, ?COCH2R7, ?CO2R7, ?CONHR7, geranyl or CH2R3; R6 is hydrogen or lower alkyl; R7 is geranyl and any moiety selected from R other than AR5 A and B are, independently, ?O?, ?S? or ?NR6 ?; and a is 0-8; b is 1-10 when Y=S, and 2-10 when Y=0; c is 1-3; d is 0-9; and e is 3-18; which by virtue of their ability to inhibit PLA2, are ofuse as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals
