1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

Base Information

• Chemical Name: 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)
• CAS No.: 192214-06-5
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.266
• Hs Code.: 2933990090
• Mol file: 192214-06-5.mol

Synonyms:1,3-Pyrrolidinedicarboxylicacid, 1-(phenylmethyl) ester, (R)-;(R)-1-Cbz-Pyrrolidine-3-carboxylic acid;(3R)-1-Benzyloxycarbonylpyrrolidine-3-carboxylic acid;

Chemical Property of 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

Chemical Property:

• Vapor Pressure: 3.06E-08mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 432.3 °C at 760 mmHg
• Flash Point: 215.3 °C
• PSA: 66.84000
• Density: 1.309 g/cm³
• LogP: 1.66760
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Cbz-pyrrolidine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

There total 19 articles about 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (192214-05-4) → (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid (192214-06-5)

Guidance literature:

With chromium(VI) oxide; In acetone; at 0 ℃;

DOI:10.1021/jo9701905

Reference yield: 65.0%

3-cyanopyrrolidine-1-carboxylic acid benzyl ester (329012-80-8) → (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid (192214-06-5)

Guidance literature:

With hydrogenchloride; In methanol; water; for 72h; Ambient temperature;

DOI:10.1016/S0960-894X(97)00311-9

Reference yield: 39.0%

benzyl chloroformate (501-53-1,94274-21-2) + (R)-(3)-pyrrolidinecarboxylic acid (72580-54-2) → (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid (192214-06-5)

Guidance literature:

With sodium hydroxide; In water; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2017.04.005

upstream raw materials:

3-cyanopyrrolidine-1-carboxylic acid benzyl ester

benzyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

(R)-4-(hydroxymethyl)dihydrofuran-2(3H)-one

benzyl chloroformate

Downstream raw materials:

(R)-methyl-1-benzyloxycarbonyl-pyrrolidine-3-carboxylate

(R)-methyl-1-tert-butoxycarbonyl-pyrrolidine-3-carboxylate

trans-3-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(R)-pyrrolidin-1-carboxylic acid tert-butyl ester

1-benzyl 3-(tert-butyl) (R)-pyrrolidine-1,3-dicarboxylate

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