(R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

Base Information

• Chemical Name: (R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate
• CAS No.: 1217655-90-7
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.28908
• Mol file: 1217655-90-7.mol

Synonyms:(R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate;(R)-1-Cbz-3-pyrrolidine carboxylic Acid Methyl Ester

Chemical Property of (R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

Chemical Property:

• PSA: 55.84000
• LogP: 1.75600
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Benzyl3-methylpyrrolidine-1,3-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate

There total 13 articles about (R)-1-benzyl 3-Methyl pyrrolidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid (188527-21-1) + methyl iodide (74-88-4) → pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester (188847-00-9,1217655-90-7)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield: 91.0%

methanol (67-56-1) + (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid (192214-06-5) → (R)-methyl-1-benzyloxycarbonyl-pyrrolidine-3-carboxylate (1217655-90-7)

Guidance literature:

With hydrogenchloride; at 35 ℃; for 1.5h;

Reference yield: 91.0%

pyrrolidine-3-carboxylic acid methyl ester hydrochloride (198959-37-4) + benzyl chloroformate (501-53-1,94274-21-2) → pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester (188847-00-9,1217655-90-7)

Guidance literature:

With sodium hydrogencarbonate; In water; toluene; at 0 - 20 ℃; for 6h;

DOI:10.3390/molecules24101901

upstream raw materials:

(R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid

methyl iodide

pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

methanol

Downstream raw materials:

(R)-methyl-1-tert-butoxycarbonyl-pyrrolidine-3-carboxylate

trans-3-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(R)-pyrrolidin-1-carboxylic acid tert-butyl ester

C₁₄H₁₇NO₄

(R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid