2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

Base Information

Chemical Name:2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole
CAS No.:284663-51-0
Molecular Formula:C₁₅H₁₄INO₃
Molecular Weight:383.186
Hs Code.:

Synonyms:2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

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Chemical Property of 2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

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Technology Process of 2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

There total 5 articles about 2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 284663-49-6
N,N-dimethyl 2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole-1-sulfonamide

: 284663-51-0
2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 65 ℃; for 4h;
DOI:10.1021/jo9915224

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 284663-51-0
2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Pd(PPh₃)4; Na₂SO₄ / methanol; toluene / 2 h / 90 - 100 °C

2: 83 percent / CF₃CO₂Ag; I₂ / tetrahydrofuran / 6 h / -78 °C

3: 84 percent / n-Bu₄NF / tetrahydrofuran / 4 h / 65 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; iodine; silver trifluoroacetate; sodium sulfate; In tetrahydrofuran; methanol; toluene; 1: Phenylation / 2: Iodination / 3: Elimination;
DOI:10.1021/jo9915224

Reference yield:

: 284663-47-4
N,N-dimethyl 2-iodo-3-(trans-2-methoxycarbonylethenyl)-4-trimethylsilyl-1H-pyrrole-1-sulfonamide

: 284663-51-0
2-(p-methoxyphenyl)-3-(trans-2-methoxycarbonylethenyl)-4-iodo-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Pd(PPh₃)4; Na₂SO₄ / methanol; toluene / 2 h / 90 - 100 °C

2: 83 percent / CF₃CO₂Ag; I₂ / tetrahydrofuran / 6 h / -78 °C

3: 84 percent / n-Bu₄NF / tetrahydrofuran / 4 h / 65 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; iodine; silver trifluoroacetate; sodium sulfate; In tetrahydrofuran; methanol; toluene; 1: Phenylation / 2: Iodination / 3: Elimination;
DOI:10.1021/jo9915224