1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Base Information

• Chemical Name: 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione
• CAS No.: 1462367-32-3
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 1462367-32-3.mol

Synonyms:1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Chemical Property of 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

There total 4 articles about 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(S)-2-{[(4-methoxyphenyl)methyl][methyl(phenyl)carbamoyl]amino}propanoic acid → 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione (1462367-32-3)

Guidance literature:

With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc46193a

Reference yield:

ethyl (S)-2-{[(4-methoxyphenyl)methyl][methyl(phenyl)carbamoyl]amino}propanoate → 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione (1462367-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 20 h / 45 °C / Inert atmosphere

2: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With lithium chloride; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; water;

DOI:10.1039/c3cc46193a

Reference yield:

ethyl (S)-2-{[(4-methoxyphenyl)methyl]amino}propanoate → 1-[(4-methoxyphenyl)methyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione (1462367-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dimethoxyethane / 0.17 h / Inert atmosphere

1.2: 20 h / Inert atmosphere; Reflux

2.1: lithium hydroxide / water; tetrahydrofuran / 20 h / 45 °C / Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With triethylamine; lithium chloride; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; water;

DOI:10.1039/c3cc46193a

upstream raw materials:

4-methoxy-benzaldehyde

Downstream raw materials:

3,5-dimethyl-5-phenylimidazolidine-2,4-dione

2-amino-2-phenylpropanoic acid

2-amino-2-phenyl propanoate de methyle