2-(Boc-amino)-6-oxospiro[...

Base Information

• Chemical Name: 2-(Boc-amino)-6-oxospiro[...
• CAS No.: 1118786-86-9
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.288
• Hs Code.: 2924190090
• Mol file: 1118786-86-9.mol

Synonyms:(6-oxyspiro[3.3]heptan-2-yl)carbamic acid tert-butyl ester

Chemical Property of 2-(Boc-amino)-6-oxospiro[...

Chemical Property:

• Melting Point: 94 °C
• Boiling Point: 360.3±41.0 °C(Predicted)
• PKA: 12.26±0.20(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Boc-amino)-6-oxospiro[3.3]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Boc-amino)-6-oxospiro[...

There total 2 articles about 2-(Boc-amino)-6-oxospiro[... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(6-hydroxyspiro[3.3]hept-2-yl)carbamic acid tert-butyl ester → (6-oxyspiro[3.3]heptan-2-yl)carbamic acid tert-butyl ester (1118786-86-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

C8H9N3O2 + tert-butyl alcohol (75-65-0) → (6-oxyspiro[3.3]heptan-2-yl)carbamic acid tert-butyl ester (1118786-86-9)

Guidance literature:

C₈H₉N₃O₂; In toluene; at 90 ℃;

tert-butyl alcohol; In toluene; at 90 ℃; for 16h;

DOI:10.1021/jo101271h

Reference yield: 98.0%

dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate (61260-15-9) + (6-oxyspiro[3.3]heptan-2-yl)carbamic acid tert-butyl ester (1118786-86-9) → tert-butyl (6-(3-oxoisobenzofuran-1(3H)-ylidene)spiro[3.3]heptan-2-yl)carbamate

Guidance literature:

With caesium carbonate; In isopropyl alcohol; at 20 ℃; for 16h;

upstream raw materials:

tert-butyl alcohol

Refernces

• 1、 Radchenko, Dmytro S.,Pavlenko, Sergiy O.,Grygorenko, Oleksandr O.,Volochnyuk, Dmitriy M.,Shishkina, Svitlana V.,Shishkin, Oleg V.,Komarov, Igor V.. "Cyclobutane-derived diamines: Synthesis and molecular structure". experimental part. p. 5941 - 5952. Retrieved 2010/11/04.