2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

Base Information

Chemical Name:2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide
CAS No.:388612-79-1
Molecular Formula:C₂₆H₃₂FN₃O₄Si
Molecular Weight:497.642
Hs Code.:

Synonyms:2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

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Chemical Property of 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

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Technology Process of 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

There total 8 articles about 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388612-78-0
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

: 388612-79-1
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 388612-69-9
3-(2-fluoro-3-iodophenyl)-1-[(2-(trimethylsilyl)-ethoxymethyl)]quinoxalin-2(1H)-one

: 388612-79-1
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

2: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 12 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 388612-66-6
Ethyl (2-fluoro-3-iodophenyl)oxoacetate

: 388612-79-1
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-benzohydroxamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 15 h / 120 °C

2: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

4: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 12 h / 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; tetrabutyl ammonium fluoride; water; sodium hydride; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;