2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

Base Information

Chemical Name:2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide
CAS No.:388612-78-0
Molecular Formula:C₃₂H₄₆FN₃O₄Si₂
Molecular Weight:611.904
Hs Code.:

2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

Synonyms:2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

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Chemical Property of 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

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Technology Process of 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

There total 7 articles about 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388612-77-9
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl]benzoic acid

: 388612-76-8
N-cyclopentyl-O-tert-butyldimethylsilyl-hydroxylamine

: 388612-78-0
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

Guidance literature:: With 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine; In chloroform; at 20 ℃; for 12h;

Reference yield:

: 388612-69-9
3-(2-fluoro-3-iodophenyl)-1-[(2-(trimethylsilyl)-ethoxymethyl)]quinoxalin-2(1H)-one

: 388612-78-0
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

2: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 12 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 388612-66-6
Ethyl (2-fluoro-3-iodophenyl)oxoacetate

: 388612-78-0
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydro-quinoxalin-2-yl]-N-cyclopentyl-O-tert-butyldimethylsilylbenzohydroxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 15 h / 120 °C

2: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

4: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 12 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydride; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;