4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE

Base Information

• Chemical Name: 4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE
• CAS No.: 191847-82-2
• Molecular Formula: C₈H₄ClF₃N₂O
• Molecular Weight: 236.581
• Mol file: 191847-82-2.mol

Synonyms:4-Chloro-6-trifluoromethyl-1,3-dihydrobenzimidazol-2-one

Chemical Property of 4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE

Chemical Property:

• PSA: 48.65000
• LogP: 2.52840

Purity/Quality:

95% ^*data from raw suppliers

4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE

There total 3 articles about 4-CHLORO-6-TRIFLUOROMETHYLBENZIMIDAZOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester (191847-73-1) → 4-chloro-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one (191847-82-2) + 7-chloro-5-trifluoromethyl-1H-benzimidazole 3-oxide + 5-chloro-1-hydroxy-7-trifluoromethylquinoxaline-2,3-(1H,4H)-dione + 2,2'-diamino-3,3'-dichloro-5,5'-bis(trifluoromethyl)azoxybenzene

Guidance literature:

With barium dihydroxide; In tetrahydrofuran; for 19h; Ambient temperature;

DOI:10.1039/a607378f

Reference yield:

5-Chloro-4-fluoro-3-nitro-trifluoromethylbenzene (101646-02-0) → 4-chloro-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one (191847-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NaHCO₃ / methanol / 2 h / Heating

2: Ba(OH)2 / tetrahydrofuran / 19 h / Ambient temperature

With barium dihydroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol;

DOI:10.1039/a607378f

Reference yield:

→ 4-chloro-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one (191847-82-2)

Guidance literature:

upstream raw materials:

N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester

5-Chloro-4-fluoro-3-nitro-trifluoromethylbenzene

Refernces

• 1、 Collins Cafiero, Pamela A.,French, Colin S.,McFarlane, Michael D.,Mackie, Raymond K.,Smith, David M.. "O-Nitroaniline derivatives. Part 14. Cyclisations leading to benzimidazole N-oxides, N-hydroxybenzimidazolones and N-hydroxyquinoxaline-2,3-diones: A mechanistic borderline". . p. 1375 - 1384. Retrieved 2007/10/03.