N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester

Base Information

• Chemical Name: N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester
• CAS No.: 191847-73-1
• Molecular Formula: C₁₀H₈ClF₃N₂O₄
• Molecular Weight: 312.633
• Mol file: 191847-73-1.mol

Synonyms:N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester

Chemical Property of N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester

There total 1 articles about N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 5-Chloro-4-fluoro-3-nitro-trifluoromethylbenzene (101646-02-0) → N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester (191847-73-1)

Guidance literature:

With sodium hydrogencarbonate; In methanol; for 2h; Heating;

DOI:10.1039/a607378f

Reference yield: 31.0%

N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester (191847-73-1) → 7-chloro-5-trifluoromethyl-1H-benzimidazole 3-oxide + 5-chloro-1-hydroxy-7-trifluoromethylquinoxaline-2,3-(1H,4H)-dione + 2,2'-diamino-3,3'-dichloro-5,5'-bis(trifluoromethyl)azoxybenzene

Guidance literature:

With triethylamine; In toluene; 1.) room temp., 2 h, 2.) 75 deg C, 1 h, 3.) 80-90 deg C 4 h;

DOI:10.1039/a607378f

Reference yield: 17.0%

N-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]glycine methyl ester (191847-73-1) → 4-chloro-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one (191847-82-2) + 7-chloro-5-trifluoromethyl-1H-benzimidazole 3-oxide + 5-chloro-1-hydroxy-7-trifluoromethylquinoxaline-2,3-(1H,4H)-dione + 2,2'-diamino-3,3'-dichloro-5,5'-bis(trifluoromethyl)azoxybenzene

Guidance literature:

With barium dihydroxide; In tetrahydrofuran; for 19h; Ambient temperature;

DOI:10.1039/a607378f

upstream raw materials:

glycine ethyl ester hydrochloride

5-Chloro-4-fluoro-3-nitro-trifluoromethylbenzene

Downstream raw materials:

4-chloro-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one