Technology Process of (1S,2S,4R,5S)-4-Allyloxy-5-hydroxy-cyclohexane-1,2-dicarboxylic acid dimethyl ester
There total 3 articles about (1S,2S,4R,5S)-4-Allyloxy-5-hydroxy-cyclohexane-1,2-dicarboxylic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid dimethyl ester;
With
di(n-butyl)tin oxide;
In
benzene;
for 6h;
Heating;
allyl bromide; a;
With
tetra-(n-butyl)ammonium iodide; cesium fluoride;
In
benzene;
at 20 ℃;
for 48h;
Further stages.;
DOI:10.1021/jo015570b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / H2SO4 / 20 h / Heating
2.1: 99 percent / Et3NO; OsCl3; H2O / CH2Cl2 / 15 h / 20 °C
3.1: Bu2SnO / benzene / 6 h / Heating
3.2: 73 percent / Bu4NI; CsF / benzene / 48 h / 20 °C
With
osmium (III) chloride; triethylamine N-oxide; sulfuric acid; water; di(n-butyl)tin oxide;
In
dichloromethane; benzene;
1.1: Fischer esterification;
DOI:10.1021/jo015570b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 99 percent / Et3NO; OsCl3; H2O / CH2Cl2 / 15 h / 20 °C
2.1: Bu2SnO / benzene / 6 h / Heating
2.2: 73 percent / Bu4NI; CsF / benzene / 48 h / 20 °C
With
osmium (III) chloride; triethylamine N-oxide; water; di(n-butyl)tin oxide;
In
dichloromethane; benzene;
DOI:10.1021/jo015570b
