(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

Base Information

Chemical Name:(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate
CAS No.:1422739-91-0
Molecular Formula:C₂₂H₁₇ClN₄O₄
Molecular Weight:436.854
Hs Code.:

Synonyms:(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

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Chemical Property of (RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

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Technology Process of (RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

There total 4 articles about (RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1422739-84-1
C₁₈H₁₅ClN₄O₂

: 95-92-1
oxalic acid diethyl ester

: 1422739-91-0
(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

Guidance literature:: In ethanol; for 4h; Reflux;
DOI:10.1016/j.ejmech.2012.11.011

Reference yield:

: 326918-74-5
(RS)-2-amino-4-(4-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile

: 1422739-91-0
(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 4 h / Reflux

2: hydrazine hydrate / ethanol / 1 h / 20 °C

3: ethanol / 4 h / Reflux

With hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2012.11.011

Reference yield:

: 130944-03-5
2-Amino-4-(4-chloro-phenyl)-7-hydroxy-4H-chromene-3-carbonitrile

: 1422739-91-0
(RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 1 h / 20 °C

1.2: 24 h / Reflux

2.1: 4 h / Reflux

3.1: hydrazine hydrate / ethanol / 1 h / 20 °C

4.1: ethanol / 4 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol;
DOI:10.1016/j.ejmech.2012.11.011