Technology Process of (S)-4-benzyl-3-((2S,3R)-2-bromo-4,4,4-trifluoro-3-methylbutanoyl)-oxazolidin-2-one
There total 3 articles about (S)-4-benzyl-3-((2S,3R)-2-bromo-4,4,4-trifluoro-3-methylbutanoyl)-oxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-methylbutanoyl)oxazolidin-2-one;
With
di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 - 0 ℃;
With
N-Bromosuccinimide;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1039/c2ob26810h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran; dichloromethane / 0.5 h / 20 °C
1.2: -78 °C / Schlenk technique
2.1: N-ethyl-N,N-diisopropylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / -78 - 0 °C
2.2: -78 - 20 °C
With
ytterbium(III) trifluoromethanesulfonate hydrate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/c2ob26810h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 2 h / -78 °C
2.1: ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran; dichloromethane / 0.5 h / 20 °C
2.2: -78 °C / Schlenk technique
3.1: N-ethyl-N,N-diisopropylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / -78 - 0 °C
3.2: -78 - 20 °C
With
n-butyllithium; ytterbium(III) trifluoromethanesulfonate hydrate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c2ob26810h
