90719-30-5Relevant articles and documents
RAS INHIBITORS
-
Paragraph 0957; 0958, (2021/05/07)
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Regioselective, Photocatalytic α-Functionalization of Amines
Leng, Lingying,Fu, Yue,Liu, Peng,Ready, Joseph M.
supporting information, p. 11972 - 11977 (2020/08/06)
Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.
Palladium-Catalyzed Diastereoselective Synthesis of 3-Arylbutanoic Acid Derivatives
Zhi, Wubin,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Wu, Yangjie
, p. 12286 - 12293 (2017/12/08)
The first palladium-catalyzed diastereoselective conjugate addition of arylboronic acids to chiral imides is reported. The catalytic system employing 4-tert-butyloxazolidin-2-one as the chiral auxiliary in a mixed solvent system of MeOH/H2O (1:3) under an air atmosphere provides the optically active 3-arylbutanoic acid derivatives in excellent yields with high diastereoselectivity.
THIOPHEN-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS INHIBITORS OF FLAVIVIRIDAE VIRUSES
-
Page/Page column 31; 32, (2013/03/26)
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug
Conjugate hydrotrifluoromethylation of α,β-unsaturated acyl-oxazolidinones: Synthesis of chiral fluorinated amino acids
Erdbrink, Holger,Peuser, Ilona,Gerling, Ulla I. M.,Lentz, Dieter,Koksch, Beate,Czekelius, Constantin
supporting information, p. 8583 - 8586 (2013/01/15)
A novel conjugate hydrofluoroalkylation of α,β-unsaturated acyl-oxazolidinones is described. Using this method, enantiomerically pure β-trifluoromethylated amino acids were prepared. Trifluorovaline and trifluoroisoleucine were incorporated into peptides and found to show extremely low α-helix propensities.
Stereoselective synthesis of an alarm pheromone of Grematogaster ants using (4S)-4-benzyloxazolidinone as chiral auxiliary
Zhou,Lu,Chen,Yang
experimental part, p. 83 - 85 (2010/08/20)
(S)-6-Methyl-3-octanone, a component of the alarm pheromone of Grematogaster ants, was synthesized through a key step of stereoselective Michael addition reaction using (4S)-4-benzyloxazolidinone as chiral auxiliary. The target product was obtained with a
Stereoselective synthesis of the sex pheromone of the yellow mealworm using (S)-4-benzyloxazolidinone as chiral auxiliary
Li,Lu,Yang,Chen
experimental part, p. 440 - 443 (2010/10/02)
(R)-4-Methyl-1-nonanol, the sex pheromone of the yellow mealworn (Tenebrio molitor L.), was synthesized with high stereoselectivity using (S)-4-benzyloxazolidinone as chiral auxiliary. The stereoselective synthesis was achieved by asymmetric Michael addit
Doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure N-enoyl oxazolidin-2-ones: A mechanistic probe
Davies, Stephen G.,Fletcher, Ai M.,Hermann, Gesine J.,Poce, Giovanna,Roberts, Paul M.,Smith, Andrew D.,Sweet, Miles J.,Thomson, James E.
experimental part, p. 1635 - 1648 (2010/10/18)
The doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-N-(α-methylbenzyl)amide to a range of enantiopure N-enoyl oxazolidin-2-ones has been used as a mechanistic probe to determine that the reactive conformation is the anti-s-cis form. The β-amino carbonyl products resulting from these conjugate addition reactions are useful templates for further elaboration into an α,β,α-pseudotripeptide.
A concise diels-alder strategy for the asymmetric synthesis of (+)-albicanol, (+)-albicanyl acetate, (+)-dihydrodrimenin, and (-)-dihydroisodrimeninol
Henderson, Jeff R.,Parvez, Masood,Keay, Brian A.
supporting information; experimental part, p. 3178 - 3181 (2009/12/05)
A short, mild, highly diastereo-, regio-, and stereoselective Diels-Alder strategy has been developed for the asymmetric synthesis of (+)albicanol, (+)-albicanyl acetate, (+)-dihydrodrimenin, and (-)-dihydroisodrimeninol.
Stereocontrolled total synthesis of (-)-kainic acid
Sakaguchi, Hiroshi,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 1635 - 1638 (2008/02/02)
A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant
