3-ethyl-2-phenylbenzo[b]oxepine

Base Information

• Chemical Name: 3-ethyl-2-phenylbenzo[b]oxepine
• CAS No.: 1510865-07-2
• Molecular Formula: C₁₈H₁₆O
• Molecular Weight: 248.324
• Mol file: 1510865-07-2.mol

Synonyms:3-ethyl-2-phenylbenzo[b]oxepine

Chemical Property of 3-ethyl-2-phenylbenzo[b]oxepine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-ethyl-2-phenylbenzo[b]oxepine

There total 2 articles about 3-ethyl-2-phenylbenzo[b]oxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-phenyl-1-butyne (622-76-4,83585-27-7) + 2-allylphenol (695-84-1) → 3-ethyl-2-phenylbenzo[b]oxepine (1510865-07-2)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In acetonitrile; at 85 ℃; Sealed tube;

DOI:10.1021/ja410538w

Reference yield:

salicylaldehyde (90-02-8) → 3-ethyl-2-phenylbenzo[b]oxepine (1510865-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 30 °C / Inert atmosphere

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate / acetonitrile / 85 °C / Sealed tube

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium tert-butylate; copper(II) acetate monohydrate; In tetrahydrofuran; acetonitrile; 1: |Wittig Olefination;

DOI:10.1021/ja410538w

upstream raw materials:

salicylaldehyde

1-phenyl-1-butyne

2-allylphenol