3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

Base Information

Chemical Name:3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide
CAS No.:1186234-32-1
Molecular Formula:C₂₃H₂₅N₅O₅
Molecular Weight:451.482
Hs Code.:

Synonyms:3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

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Chemical Property of 3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

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Technology Process of 3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

There total 9 articles about 3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186234-61-6
C₁₀H₁₅BO₅

: 1186234-56-9
3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyridazin-3-ylamide

: 1186234-32-1
3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1186234-32-1
3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

1.2: 70 °C / Inert atmosphere

2.1: dichloromethane / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice; Inert atmosphere

3.2: 20 °C / Cooling with ice; Inert atmosphere

4.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 124764-37-0
3-bromo-4-methoxyphenyl acetate

: 1186234-32-1
3-{5-[2-methoxy-5-(2-methoxy-ethoxy)-phenyl]-pyridin-2-yloxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / methanol / 0.5 h / 20 °C

1.2: Acidic aqueous solution

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexanes / -78 - 20 °C / Cooling with acetone-dry ice; Inert atmosphere

4.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With n-butyllithium; Triisopropyl borate; water; sodium hydrogencarbonate; potassium carbonate; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; hexanes; water; N,N-dimethyl-formamide;