1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

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Chemical Name:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid
CAS No.:952675-01-3
Molecular Formula:C₂₂H₂₆F₂N₄O₄S
Molecular Weight:480.536
Hs Code.:

Synonyms:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

There total 11 articles about 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 952675-00-2
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carbaldehyde

: 952675-01-3
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: With Oxone; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 351-32-6
N-(4-fluoro-3-nitrophenyl)acetamide

: 952675-01-3
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / ethanol / 48 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 2327.23 Torr

3.1: dmap / dichloromethane / 2 h / 20 °C

3.2: 2.5 h / 150 °C / Sealed tube

4.1: hydrogenchloride / ethanol / 1 h / 150 °C / Sealed tube

5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

5.2: 5 h / -20 - 0 °C

6.1: dmap / 1,1-dichloroethane / 3 h / 0 - 20 °C

7.1: Oxone / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; Oxone; hydrogen; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In 1,1-dichloroethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 809273-64-1
tert-butyl (4,4-difluorocyclohexyl)methylcarbamate

: 952675-01-3
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; acetic acid / 2 h / 20 °C

2.1: triethylamine / ethanol / 48 h / 80 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 2327.23 Torr

4.1: dmap / dichloromethane / 2 h / 20 °C

4.2: 2.5 h / 150 °C / Sealed tube

5.1: hydrogenchloride / ethanol / 1 h / 150 °C / Sealed tube

6.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

6.2: 5 h / -20 - 0 °C

7.1: dmap / 1,1-dichloroethane / 3 h / 0 - 20 °C

8.1: Oxone / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; Oxone; hydrogen; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In 1,1-dichloroethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;