351-32-6

Usage

Uses

Used in Organic Synthesis:
N-(4-fluoro-3-nitrophenyl)acetamide is used as a building block in organic synthesis for the creation of various functional materials and compounds due to its unique molecular structure and reactivity.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(4-fluoro-3-nitrophenyl)acetamide is utilized as a precursor in drug development, leveraging its chemical properties to contribute to the discovery of new therapeutic agents.
Used in Antimicrobial Applications:
N-(4-fluoro-3-nitrophenyl)acetamide is employed as an antimicrobial agent, capitalizing on its ability to combat microbial infections, making it a valuable component in the development of new antimicrobial drugs.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, N-(4-fluoro-3-nitrophenyl)acetamide is used in the development of anti-inflammatory medications, potentially offering new treatment options for inflammatory conditions.
It is crucial to handle N-(4-fluoro-3-nitrophenyl)acetamide with care and adhere to safety protocols to mitigate any health and environmental risks associated with its use.

InChI:InChI=1/C8H7FN2O3/c1-5(12)10-6-2-3-7(9)8(4-6)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 364-76-1 4-Fluoro-3-nitroaniline 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 28166-06-5 4-fluoro-3-nitrophenylazide 
• 507-09-5 tiolacetic acid 

Downstream Products

• 117131-27-8 N-(4-acetamido-2-nitrophenyl)glycine ethyl ester 
• 809237-74-9 N-{4-[(cyclohexylmethyl)amino]-3-nitrophenyl}acetamide 
• 849351-32-2 N-{3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}acetamide 
• 113596-04-6 N-(3-amino-4-fluorophenyl)-acetamide 
• 562826-38-4 3-Nitro-4-(ethylamino)acetanilide 
• 881413-60-1 N-(4-{[(4,4-Difluorocyclohexyl)methyl]amino}-3-nitrophenyl)acetamide 
• 881413-70-3 N-(4-{[(4-Fluorocyclohex-3-en-1-yl)methyl]amino}-3-nitrophenyl)acetamide 
• 474020-37-6 N-{4-[(cyclopropylmethyl)amino]-3-nitrophenyl}acetamide 
• 849351-15-1 N-ethyl-N-(4-fluoro-3-nitrophenyl) acetamide 
• 1344146-24-2 N-(4-oxo-5-(p-tolyl)-4,5-dihydropyrrolo[1,2-a]quinoxalin-7-yl)-acetamide 

Relevant academic research and scientific papers

Potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide against Klebsiella pneumoniae and in Vitro Toxicity Analysis

Klebsiella pneumoniae causes a wide range of community and nosocomial infections. The high capacity of this pathogen to acquire resistance drugs makes it necessary to develop therapeutic alternatives, discovering new antibacterial molecules. Acetamides are molecules that have several biological activities. However, there are no reports on the activity of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide. Based on this, this study aimed to investigate the in vitro antibacterial activity of this molecule on K. pneumoniae, evaluating whether the presence of the chloro atom improves this effect. Then, analyzing its antibacterial action more thoroughly, as well as its cytotoxic and pharmacokinetic profile, in order to contribute to future studies for the viability of a new antibacterial drug. It was shown that the substance has good potential against K. pneumoniae and the chloro atom is responsible for improving this activity, stabilizing the molecule in the target enzyme at the site. The substance possibly acts on penicillin-binding protein, promoting cell lysis. The analysis of cytotoxicity and mutagenicity shows favorable results for future in vivo toxicological tests to be carried out, with the aim of investigating the potential of this molecule. In addition, the substance showed an excellent pharmacokinetic profile, indicating good parameters for oral use.

Heterocyclic compound and application thereof

The present disclosure relates to a heterocyclic compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, an optical isomer, a raceme, a polymorphic substance, a solvate or an isotope labeled compound thereof, a pharmaceutical composition containing the heterocyclic compound, and a pharmaceutical use thereof. The heterocyclic compound disclosed by the invention is an immunomodulator, and particularly relates to an immunomodulator of a compound for activating STING.

Therapeutic Compounds

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK

This invention relates to benzimadolecarboxamides of formula (I) which are inhibitors of focal adhesion kinase, and as such are useful for treating proliferative diseases

Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof

Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure-activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the SAR associated with an X-ray structure of one of the small-molecule inhibitors bound to ITK.

Therapeutic Compounds

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I

Compounds of Formula I, or pharmaceutically acceptable salts thereof: (chemical formula to be inserted here - please see paper copy) I wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF IIII

Compounds of Formula I, or pharmaceutically acceptable salts thereof (I) wherein G, R1, R2, R3, R4, and R5 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF

Compounds of Formula I or pharmaceutically acceptable salts thereof wherein G, R1, R2, R3, R4 and R5 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.