(1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one

Base Information

• Chemical Name: (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one
• CAS No.: 152425-18-8
• Molecular Formula: C₂₇H₃₈N₄O₃
• Molecular Weight: 466.624

Synonyms:(1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one

Chemical Property of (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one

There total 12 articles about (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.0^4,8>undecan-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1S,5R,7R)-4-((2-tert-butoxy)-1(E)-ethylidene)-7-hydroxy-7-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-2-zabicyclo<3.2.1>octane (152425-17-7) → (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.04,8>undecan-11-one (152425-18-8)

Guidance literature:

With sodium sulfate; In acetonitrile; at 80 ℃;

DOI:10.1021/ja00073a057

Reference yield: 98.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1R,5S,7S)-4-((2-tert-butoxy)-1(E)-ethylidene)-7-hydroxy-7-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-2-zabicyclo<3.2.1>octane → (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.04,8>undecan-11-one (152425-18-8)

Guidance literature:

With sodium sulfate; In acetonitrile; for 0.166667h; Heating;

DOI:10.1021/ja00126a017

Reference yield:

(1S,3R,5R)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane (152425-15-5) → (1R,7R,8S)-2-((2-tert-butoxy)-1(E)-ethylidene)-7-<2-<5-(1,3-dimethylhexahydro-2-oxa-1,3,5-triazinyl)>phenyl>-4-azatricyclo<5.2.2.04,8>undecan-11-one (152425-18-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) diisopropylethylamine, MsCl, 2.) LiCl / 1.) CH₂Cl₂, -23 deg C, 1 h, 2.) CH₂Cl₂, DMF, -23 deg C to RT

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 12 h

3: NaH / benzene / 48 h / 100 °C

4: KOH / ethanol; H₂O / 3 h / 70 °C

5: 98 percent / Na₂SO₄ / acetonitrile / 0.17 h / Heating

With potassium hydroxide; sodium hydride; methanesulfonyl chloride; sodium sulfate; N-ethyl-N,N-diisopropylamine; lithium chloride; In ethanol; water; acetonitrile; benzene;

DOI:10.1021/ja00126a017

upstream raw materials:

formaldehyd

(1S,5R,7R)-4-((2-tert-butoxy)-1(E)-ethylidene)-7-hydroxy-7-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-2-zabicyclo<3.2.1>octane

(1S,3R,5R)-3-<1(E)-(1-(hydroxymethyl)-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

(1S,3R,5R)-3-<1(E)-(1-((triisopropylsilyl)oxy)methyl-3-tert-butoxypropenyl)>-1-<1-<2-<5-(1,3-dimethylhexahydro-2-oxo-1,3,5-triazinyl)>phenyl>ethenyl>-6-oxabicyclo<3.1.0>hexane

Downstream raw materials:

N(1)-desacetyl 18-hydroxyisoretuline

strychnidin-10-one

(17R,19E)-17,18-epoxy-cur-19-en-17-ol

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