1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate

Base Information

• Chemical Name: 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate
• CAS No.: 1360733-83-0
• Molecular Formula: C₁₇H₃₀O₄Si
• Molecular Weight: 326.508

Synonyms:1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate

Chemical Property of 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate

Chemical Property:

Purity/Quality:

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Technology Process of 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate

There total 4 articles about 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexan-1-ol + methyl chloroformate (79-22-1) → 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate (1360733-83-0)

Guidance literature:

1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexan-1-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl chloroformate; In tetrahydrofuran; hexane;

DOI:10.1021/ol300111m

Reference yield:

tert-Butyldimethyl(prop-2-ynyloxy)silane (76782-82-6) → 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate (1360733-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

1.2: 1 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/ol300111m

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(3-((t-butyldimethylsilyl)oxy)prop-1-yn-1-yl)cyclohexyl methyl carbonate (1360733-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

1.2: 1 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/ol300111m

upstream raw materials:

methyl chloroformate

tert-Butyldimethyl(prop-2-ynyloxy)silane

cyclohexanone

tert-butyldimethylsilyl chloride

Downstream raw materials:

methyl (1-(3-oxoprop-1-yn-1-yl)cyclohexyl)carbonate

C₁₁H₁₆O₄

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