7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester

Base Information

• Chemical Name: 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester
• CAS No.: 124286-29-9
• Molecular Formula: C₂₅H₄₁O₇P
• Molecular Weight: 484.57
• Mol file: 124286-29-9.mol

Synonyms:7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester

Chemical Property of 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester

There total 2 articles about 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydro-3,3,6-trimethyl-2H-pyran-2-one (62581-36-6) → 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester (124286-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BuLi / tetrahydrofuran / -78 °C

2: DCC, DMAP / dimethylformamide

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja00157a071

Reference yield:

7-(benzyloxy)heptanoic acid (124267-23-8) + (2-Hydroxy-3,3,6-trimethyl-tetrahydro-pyran-2-ylmethyl)-phosphonic acid dimethyl ester (124267-19-2) → 7-Benzyloxy-heptanoic acid 6-(dimethoxy-phosphoryl)-1,4,4-trimethyl-5-oxo-hexyl ester (124286-29-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00157a071

upstream raw materials:

7-(benzyloxy)heptanoic acid

(2-Hydroxy-3,3,6-trimethyl-tetrahydro-pyran-2-ylmethyl)-phosphonic acid dimethyl ester

tetrahydro-3,3,6-trimethyl-2H-pyran-2-one