5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate

Base Information

• Chemical Name: 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate
• CAS No.: 226086-98-2
• Molecular Formula: C₂₉H₃₆N₄O₆S₂
• Molecular Weight: 600.76
• Mol file: 226086-98-2.mol

Synonyms:5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate

Chemical Property of 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate

There total 4 articles about 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-(N-(2-((tert-butoxycarbonyl)amino)ethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate → 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate (226086-98-2)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01400

Reference yield: 81.0%

ethylenediamine (107-15-3,85404-18-8) + rhodamine B sulfonyl chloride (62796-29-6) → 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate (226086-98-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 13h;

DOI:10.1055/s-2008-1032172

Reference yield:

rhodamine B sulfonyl chloride (62796-29-6) → 5-(N-(2-aminoethyl)sulfamoyl)-2-(6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl)benzenesulfonate (226086-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 25 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 25 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c6cc02894b

upstream raw materials:

ethylenediamine

rhodamine B sulfonyl chloride