Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Base Information

Chemical Name:Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester
CAS No.:189340-73-6
Molecular Formula:C₂₄H₃₁NO₆S
Molecular Weight:461.579
Hs Code.:

Synonyms:Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

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Chemical Property of Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

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Technology Process of Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

There total 7 articles about Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 189340-20-3
N-[2-[4-(tert-butoxycarbonylamino)butyloxy]-4-methylphenyl]benzenesulfonamide

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 176382-26-6
benzenesulfonic acid 3-hydroxy-5-methylphenyl ester

: 1972-28-7,218603-74-8
diethylazodicarboxylate

: 189340-73-6
Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 176382-26-6
benzenesulfonic acid 3-hydroxy-5-methylphenyl ester

: 189340-73-6
Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: benzenesulfonic acid 3-hydroxy-5-methylphenyl ester; With sodium hydride; In N,N-dimethyl-formamide;

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1016/S0960-894X(99)00617-4

Reference yield:

: 498-94-2
isonipecotic acid

: 189340-73-6
Benzenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / NaHCO₃ / dioxane; H₂O / 24 h

2.1: 84 percent / BH₃*THF / 0 - 25 °C

3.1: 93 percent / Et₃N / CH₂Cl₂

4.1: NaH / dimethylformamide

4.2: dimethylformamide / 3 h / 50 °C

With borane-THF; sodium hydride; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Reduction / 3.1: Mesylation / 4.1: Metallation / 4.2: Substitution;
DOI:10.1016/S0960-894X(99)00617-4