N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide

Base Information

• Chemical Name: N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide
• CAS No.: 84574-46-9
• Molecular Formula: C₂₁H₂₂F₃NO₄
• Molecular Weight: 409.405

Synonyms:N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide

Chemical Property of N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide

Chemical Property:

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Technology Process of N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide

There total 5 articles about N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[(E)-2-(3,4-Dimethoxy-phenyl)-5-phenyl-pent-4-enyl]-2,2,2-trifluoro-acetamide → N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide (84574-46-9)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)85610-5

Reference yield:

3,4-dimethoxyphenylacetonitrile (93-17-4) → N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide (84574-46-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / LDA / tetrahydrofuran / -78 °C

2: 100 percent / AlH₃ / tetrahydrofuran

3: 91 percent

4: 100 percent / MCPBA, NaHCO₃ / CH₂Cl₂

With aluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)85610-5

Reference yield:

(E)-2-(3,4-Dimethoxy-phenyl)-5-phenyl-pent-4-enylamine → N-[2-(3,4-Dimethoxy-phenyl)-3-(3-phenyl-oxiranyl)-propyl]-2,2,2-trifluoro-acetamide (84574-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent

2: 100 percent / MCPBA, NaHCO₃ / CH₂Cl₂

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)85610-5

upstream raw materials:

3,4-dimethoxyphenylacetonitrile

(E)-2-(3,4-dimethoxyphenyl)-5-phenyl-4-pentenenitrile

Cinnamyl bromide

Downstream raw materials:

(2S,3R,5R)-5-(3,4-Dimethoxy-phenyl)-2-phenyl-piperidin-3-ol

[4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2-yl]-phenyl-methanol

(1R,8S,9S)-8-Phenyl-10-aza-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-triene-4,5-diol

(1R,8S,9S)-4,5-Dimethoxy-8-phenyl-10-aza-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-triene

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