Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

Base Information

Chemical Name:Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester
CAS No.:123207-53-4
Molecular Formula:C₁₉H₁₄FN₃O₃
Molecular Weight:351.337
Hs Code.:

Synonyms:Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

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Chemical Property of Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

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Technology Process of Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

There total 3 articles about Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 84832-00-8
(5-amino-2-fluoro-phenyl)-methanol

: 39901-94-5
2-picolinoyl chloride hydrochloride

: 123207-52-3
N-<4-fluoro-3-(hydroxymethyl)phenyl>-2-pyridinecarboxamide

: 123207-53-4
Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) 0 deg C, 0.5 h, 2.) RT, 1 h;
DOI:10.1021/jm00163a053

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 123207-53-4
Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: 60 percent / SnCl₂*2H₂O / ethyl acetate / 24 h / Heating

3: 52 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 1 h

With sodium tetrahydroborate; triethylamine; tin(ll) chloride; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00163a053

Reference yield:

: 63878-73-9
(2-fluoro-5-nitrophenyl)methanol

: 123207-53-4
Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / SnCl₂*2H₂O / ethyl acetate / 24 h / Heating

2: 52 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 1 h

With triethylamine; tin(ll) chloride; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00163a053