1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CAS No.:117566-01-5
Molecular Formula:C₁₉H₂₂BrNO₃
Molecular Weight:392.293
Hs Code.:

Synonyms:1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Chemical Property of 1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

There total 6 articles about 1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(2-Bromo-5-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

: 117566-01-5
1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; water; for 2h; Yield given; Ambient temperature;
DOI:10.1002/ardp.19883210811

Reference yield:

: 86826-93-9
2-(2-bromo-5-methoxyphenyl)acetic acid

: 117566-01-5
1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl₂); dimethylformamide / CH₂Cl₂ / 25 °C

2: Et₃N / CH₂Cl₂ / 25 °C

3: POCl₃ / CH₂Cl₂ / 12 h / Heating

4: NaBH₄ / methanol / 3 h / 23 °C

With phosgene; sodium tetrahydroborate; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In methanol; dichloromethane; 3: Bischler-Napieralski cyclization;
DOI:10.1002/ejoc.200600674

Reference yield:

: 117565-97-6
2-(2-Bromo-5-methoxyphenyl)-N-<2-(3,4-dimethoxyphenyl)-ethyl>-acetamide

: 117566-01-5
1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / CH₂Cl₂ / 12 h / Heating

2: NaBH₄ / methanol / 3 h / 23 °C

With sodium tetrahydroborate; trichlorophosphate; In methanol; dichloromethane; 1: Bischler-Napieralski cyclization;
DOI:10.1002/ejoc.200600674