117565-97-6

Upstream product

• 117565-90-9 methyl 2-(2'-bromo-5'-methoxyphenyl)acetate 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 86826-93-9 2-(2-bromo-5-methoxyphenyl)acetic acid 
• 1798-09-0 m-methoxyphenylacetic acid 
• 203314-50-5 (2-Bromo-5-methoxy-phenyl)-acetyl chloride 

Downstream Products

• 117566-08-2 5,6-Dihydro-2,3,10-trimethoxy-indolo<2,1-a>isoquinoline 
• 117566-01-5 1-(2-Bromo-5-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 934355-55-2 tert-butyl 1-(2-bromo-5-methoxybenzyl)-3,4-dihydro-6,7-dimethoxy-isoquinoline-2(1H)-carboxylate 

Relevant academic research and scientific papers

Aporphine alkaloid synthesis and diversification via direct arylation

Palladium-catalyzed direct arylation of aryl chlorides, bromides and iodides has been applied to the preparation of new aporphine analogues including C2-substituted aporphines by reaction with benzodioxole, pyridine N-oxide and pyrazine N-oxide. Successful application of direct arylation in these diversification reactions highlights its utility not only in convergent, but also in divergent synthesis. We also describe enantioselective syntheses of (R)-nornuciferine and (R)-nuciferine employing a catalytic asymmetric transfer hydrogenation in high yield and excellent enantiomeric excess. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.