ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

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Chemical Name:ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate
CAS No.:1272674-60-8
Molecular Formula:C₂₀H₁₆ClN₃O₃S
Molecular Weight:413.884
Hs Code.:

Synonyms:ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

There total 9 articles about ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.8%

: 1272674-51-7
ethyl 3-amino-5-chloro-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

: 372-09-8
cyanoacetic acid

: 1272674-60-8
ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 1272674-01-7
ethyl 3-amino-1-(4-bromophenyl)-5-chloro-1H-pyrrole-2-carboxylate

: 1272674-60-8
ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; ethanol / 0.08 h / 120 °C / microwave reactor

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1272673-93-4
ethyl 3-(acetylamino)-1H-pyrrole-2-carboxylate

: 1272674-60-8
ethyl 5-chloro-3-[(cyanoacetyl)amino]-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / chloroform / 48 h / 20 °C

2: triethylamine / copper diacetate / dichloromethane / 20 °C / Molecular sieve

3: hydrogenchloride; water / ethanol / 2 h / Reflux

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; ethanol / 0.08 h / 120 °C / microwave reactor

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;