7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Base Information

Chemical Name:7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole
CAS No.:1433663-38-7
Molecular Formula:C₂₅H₂₃F₂N₃O₃
Molecular Weight:451.473
Hs Code.:

Synonyms:7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

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Chemical Property of 7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

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Technology Process of 7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

There total 9 articles about 7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1433663-81-0
3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 1433663-38-7
7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: 3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

1-bromomethyl-3,5-difluoro-benzene; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00178

Reference yield:

: 1433663-66-1
N-(2-methoxy-4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)phenyl)formamide

: 1433663-38-7
7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 55 °C

2.1: acetic acid / 95 °C / Inert atmosphere

3.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0.5 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 1 h

With sodium tetrahydroborate; ethanol; sodium hydride; caesium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1433663-62-7
3-(4-amino-3-methoxyphenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one

: 1433663-38-7
7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride / 1 h / Cooling

2.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 55 °C

3.1: acetic acid / 95 °C / Inert atmosphere

4.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0.5 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

5.2: 1 h

With sodium tetrahydroborate; ethanol; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;