methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate

Base Information

• Chemical Name: methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate
• CAS No.: 866831-56-3
• Molecular Formula: C₁₃H₁₂F₃NO₃
• Molecular Weight: 287.238
• Mol file: 866831-56-3.mol

Synonyms:methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate

Chemical Property of methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate

Chemical Property:

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Technology Process of methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate

There total 1 articles about methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-Amino-5-trifluoromethylbenzoate (117324-58-0) + cyclopropanecarboxylic acid chloride (4023-34-1) → methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate (866831-56-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 9.0%

methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate (866831-56-3) → {2-(cyclopropylmethyl)amino-5-trifluoromethylphenyl}methanol (866829-53-0)

Guidance literature:

methyl 2-cyclopropylcarbonylamino-5-trifluoromethylbenzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

methyl 2-Amino-5-trifluoromethylbenzoate

cyclopropanecarboxylic acid chloride

Downstream raw materials:

{2-(cyclopropylmethyl)amino-5-trifluoromethylphenyl}methanol