N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

Base Information

Chemical Name:N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide
CAS No.:1179344-50-3
Molecular Formula:C₃₆H₄₇N₇O₂
Molecular Weight:609.815
Hs Code.:

N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

Synonyms:N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

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Chemical Property of N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

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Technology Process of N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

There total 4 articles about N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₅₅N₇O₄

: 1179344-50-3
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

Guidance literature:: C₄₁H₅₅N₇O₄; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

amino cartridge;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1179344-50-3
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

2.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.2: amino cartridge

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2.1: Suzuki Coupling;

Reference yield:

: 1005418-94-9
5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine monohydrochloride

: 1179344-50-3
N-{[1,6-diethyl-4-(tetrahydro-1H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

2.1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.2: amino cartridge

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2.1: Suzuki Coupling;