(S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester
• CAS No.: 175444-51-6
• Molecular Formula: C₅₄H₇₀N₆O₁₀
• Molecular Weight: 963.184

Synonyms:(S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester

Chemical Property of (S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester

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Technology Process of (S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester

There total 1 articles about (S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

BOC-glycine (4530-20-5) + (S)-2-((2S,3R)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-3-benzyloxy-butyrylamino)-4-methyl-pentanoic acid benzyl ester; compound with trifluoro-acetic acid → (S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester (175444-51-6)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1021/jm9509511

Reference yield:

(S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester (175444-51-6) → C49H75N9O11

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / Ambient temperature

2: 92 percent / BOP, DIEA / dimethylformamide / 3 h / Ambient temperature

3: H₂, AcOH / 10percent Pd/C / dimethylformamide; H₂O / 6 h / 760 Torr / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm9509511

Reference yield:

(S)-2-[(2S,3R)-3-Benzyloxy-2-((S)-2-{(S)-2-[(S)-2-(2-tert-butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester (175444-51-6) → C49H75N9O11

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / Ambient temperature

2: 92 percent / BOP, DIEA / dimethylformamide / 3 h / Ambient temperature

3: H₂, AcOH / 10percent Pd/C / dimethylformamide; H₂O / 6 h / 760 Torr / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm9509511

upstream raw materials:

BOC-glycine

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