(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Base Information

Chemical Name:(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS No.:1237533-68-4
Molecular Formula:C₂₅H₂₄BrNO₄
Molecular Weight:482.374
Hs Code.:

Synonyms:(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

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Chemical Property of (3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

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Technology Process of (3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

There total 6 articles about (3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1711-09-7
3-bromobenzoyl chloride

: 1443828-06-5
6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1237533-68-4
(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jm400177t

Reference yield:

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 1237533-68-4
(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 °C

2: trichlorophosphate / toluene / 1.5 h / Reflux

3: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; trichlorophosphate; In methanol; dichloromethane; toluene;
DOI:10.1021/jm400177t

Reference yield:

: 1443827-91-5
C₁₈H₁₉NO₃

: 1237533-68-4
(3-bromophenyl)(6-methoxy-1-((4-methoxyphenoxy)-methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm400177t