5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Base Information

Chemical Name:5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one
CAS No.:1428477-76-2
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:

Synonyms:5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

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Chemical Property of 5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

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Technology Process of 5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

There total 12 articles about 5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428477-74-0
5-[2-(4-{1-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

: 1428477-75-1
5-[2-(4-{(1S)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

: 1428477-76-2
5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: With SFC Column: AD 250mm*30mm, 5um; Resolution of racemate;

Reference yield:

: 1428478-70-9
1-(piperidin-4-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanol

: 1428477-75-1
5-[2-(4-{(1S)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

: 1428477-76-2
5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / methanol; dichloromethane / 2 h / 20 °C

2: methanol; diethylamine / Supercritical conditions; Resolution of racemate

With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; diethylamine;

Reference yield:

: 1428478-71-0
tert-butyl 4-[2-(4-bromophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

: 1428477-75-1
5-[2-(4-{(1S)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

: 1428477-76-2
5-[2-(4-{(1R)-hydroxy-2-[4-(1H-tetrazol-1-yl)phenyl]ethyl}piperidin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol; ethyl acetate / 0.5 h

3: potassium hydroxide / ethanol; water / 24 h / Reflux

4: sodium azide / ethanol / 1.5 h / 60 - 70 °C

5: hydrogenchloride / ethyl acetate / 0.5 h

6: sodium cyanoborohydride; acetic acid / methanol; dichloromethane / 2 h / 20 °C

7: methanol; diethylamine / Supercritical conditions; Resolution of racemate

With hydrogenchloride; sodium tetrahydroborate; sodium azide; palladium diacetate; sodium cyanoborohydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; diethylamine;