1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1342834-19-8
Molecular Formula:C₂₃H₁₈ClFN₄O₂S
Molecular Weight:468.939
Hs Code.:

Synonyms:1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

There total 2 articles about 1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342834-17-6
1-cyclopropyl-3-(3-fluoro-4-(2-(5-(hydroxymethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

: 1342834-19-8
1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: With thionyl chloride; In water;

Reference yield:

: 96042-30-7
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

: 1342834-19-8
1-(4-(2-(5-(chloromethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium tetrahydroborate / sodium tris(acetoxy)borohydride

2: thionyl chloride / water

With sodium tetrahydroborate; thionyl chloride; sodium hydrogencarbonate; In water; sodium tris(acetoxy)borohydride;