4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester

Base Information

• Chemical Name: 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester
• CAS No.: 279220-37-0
• Molecular Formula: C₂₃H₃₀N₂O₄
• Molecular Weight: 398.502

Synonyms:4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester

Chemical Property of 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester

Chemical Property:

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Technology Process of 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester

There total 2 articles about 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1H)-one (248246-95-9) + 5-(N,N'-dicyclohexyl-carbamimidoyloxy)-5-oxo-pentanoic acid methyl ester → 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester (279220-37-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane; at 0 - 20 ℃; for 19h;

DOI:10.1021/jm991125l

Reference yield:

Pentanedioic acid, monomethyl ester (1501-27-5) → 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester (279220-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxybenzotriazole / CH₂Cl₂ / 0.58 h / 0 °C

2: hydroxybenzotriazole; N-methylmorpholine / CH₂Cl₂ / 19 h / 0 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane;

DOI:10.1021/jm991125l

Reference yield: 74.0%

4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid methyl ester (279220-37-0) → 4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid (279220-41-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.0833333h;

DOI:10.1021/jm991125l

upstream raw materials:

3-amino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1H)-one

Pentanedioic acid, monomethyl ester

Downstream raw materials:

4-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-butyric acid

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