248246-95-9Relevant articles and documents
3-(Amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases
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, (2008/06/13)
The present invention is concerned with 3-(amino- or aminoalkyl)pyridinone derivatives which inhibit the reverse transcriptase of the Human Immunodeficiency Virus (HIV). It relates moreover to the use of such compounds for treating HIV-related diseases. F
Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
Dolle,Nguyen, Chi Hung,Legraverend,Aubertin,Kirn,Andreola,Ventura,Tarrago-Litvak,Bisagni
, p. 3949 - 3962 (2007/10/03)
Several 4-benzyl analogues of 5-ethyl-6-methyl-4-(phenylthio)pyridin-2(1H)-ones were synthesized and evaluated for their anti-HIV-1 activities. Key transformations include metalation at the 4-C-position of 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridin