N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

Base Information

Chemical Name:N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide
CAS No.:312283-49-1
Molecular Formula:C₅₇H₇₅N₁₁O₁₇S₃
Molecular Weight:1282.48
Hs Code.:

N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

Synonyms:N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

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Chemical Property of N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

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Technology Process of N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

There total 16 articles about N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 312283-43-5
N-[4-(2-cyanoethyl)-7-hydroxy-4-azaheptan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

: 312283-48-0
N-(12-tert-butoxycarbonylamino-4,9-bis(2-nitrobenzenesulfonyl)-4,9-diazadodecan-1-yl)-2-nitrobenzenesulfonamide

: 312283-49-1
N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; benzene; at 20 ℃; for 0.166667h;
DOI:10.1248/cpb.48.1570

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 312283-49-1
N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / ethanol / 0.5 h

2: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3: 81 percent / K₂CO₃ / dimethylformamide / 0.5 h / 60 °C

4: 97 percent / Cs₂CO₃; nBu₄NI / acetonitrile / 1 h / 60 °C

5: 99 percent / Ph₃P; Pd(PPh₃)4; pyrrolidine / CH₂Cl₂ / 1.5 h / 20 °C

6: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

7: 90 percent / Ph₃P; DEAD / CH₂Cl₂; benzene; toluene / 0.17 h / 20 °C

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1248/cpb.48.1570

Reference yield:

: 240423-09-0
N-(6-aminopropyl)-2-nitrobenzenesulfonamide

: 312283-49-1
N-[20-tert-butoxycarbonylamino-4-(2-cyanoethyl)-8,12,17-tris(2-nitrobenzenesulfonyl)-4,8,12,17-tetraazaicosan-1-yl]-1-tert-butoxycarbonyl-indole-3-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 81 percent / K₂CO₃ / dimethylformamide / 0.5 h / 60 °C

3: 97 percent / Cs₂CO₃; nBu₄NI / acetonitrile / 1 h / 60 °C

4: 99 percent / Ph₃P; Pd(PPh₃)4; pyrrolidine / CH₂Cl₂ / 1.5 h / 20 °C

5: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

6: 90 percent / Ph₃P; DEAD / CH₂Cl₂; benzene; toluene / 0.17 h / 20 °C

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1248/cpb.48.1570