4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester
• CAS No.: 1204300-55-9
• Molecular Formula: C₂₂H₃₀FN₃O₄
• Molecular Weight: 419.496
• Mol file: 1204300-55-9.mol

Synonyms:4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester

Chemical Property of 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester

There total 1 articles about 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{3-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester (1204302-07-7) + 2-fluoro-2-methylpropanoic acid (63812-15-7) → 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester (1204300-55-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester (1204300-55-9) → 4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid (1204300-72-0)

Guidance literature:

4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid methyl ester; With lithium hydroxide monohydrate; water; In methanol; at 50 ℃; for 12h;

With hydrogenchloride; In water; pH=3;

upstream raw materials:

4-{3-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester

2-fluoro-2-methylpropanoic acid

Downstream raw materials:

4-(3-{1-[5-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-3-yl]piperidin-4-yl}-propoxy)-2-methylbenzoic acid