(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE

Base Information

• Chemical Name: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE
• CAS No.: 191231-58-0
• Molecular Formula: C11H22 N2 O2
• Molecular Weight: 214.3
• Hs Code.: 2933990090
• Mol file: 191231-58-0.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 2-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property of (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE

Chemical Property:

• Boiling Point: 282℃
• PKA: 10.17±0.10(Predicted)
• Flash Point: 124℃
• PSA: 41.57000
• Density: 1.004
• LogP: 1.93410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl2-((methylamino)methyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE

There total 12 articles about (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C13H21F3N2O3 (475106-27-5) → (2S)-2-(methylaminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (191231-58-0)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1016/j.bmcl.2010.12.078

Reference yield:

N-methyl-N-allylamine (627-37-2) + N-(tert-butoxycarbonyl)-L-prolinol (69610-40-8) → (2S)-2-(methylaminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (191231-58-0)

Guidance literature:

N-(tert-butoxycarbonyl)-L-prolinol; With sulfur trioxide pyridine complex; trifluoroacetic acid; In dichloromethane; for 2h;

N-methyl-N-allylamine; With sodium tris(acetoxy)borohydride; In dichloromethane; for 0.5h;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

C14H26N2O2 → (2S)-2-(methylaminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (191231-58-0)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾; Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2020.127496

upstream raw materials:

(S)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

C₁₃H₂₁F₃N₂O₃

(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

N-(tert-butoxycarbonyl)-L-prolinol

Downstream raw materials:

C₂₃H₂₈N₆O

C₃₃H₄₄N₆O₅

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