4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide

Base Information

• Chemical Name: 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide
• CAS No.: 635695-47-5
• Molecular Formula: C₁₉H₂₀O₂S
• Molecular Weight: 312.433
• Mol file: 635695-47-5.mol

Synonyms:4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide

Chemical Property of 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide

There total 3 articles about 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-but-3-yn-2-ol (115-19-5) + 1-bromo-4-[(4-imethoxybenzyl)thio]benzene (635695-44-2) → 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide (635695-47-5)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; for 12h; Heating;

DOI:10.1055/s-2003-41451

Reference yield:

para-bromobenzenethiol (106-53-6) → 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide (635695-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 0.17 h

1.2: 89 percent / dimethylformamide / 13 h / 20 - 100 °C

2.1: 92 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂ / 12 h / Heating

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide;

DOI:10.1055/s-2003-41451

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 4-(3-hydroxy-3-methylbutynyl)phenyl 4-methoxybenzyl sulfide (635695-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 0.17 h

1.2: 89 percent / dimethylformamide / 13 h / 20 - 100 °C

2.1: 92 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂ / 12 h / Heating

With copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide;

DOI:10.1055/s-2003-41451

upstream raw materials:

2-methyl-but-3-yn-2-ol

1-bromo-4-[(4-imethoxybenzyl)thio]benzene

para-bromobenzenethiol

p-methoxybenzyl chloride

Downstream raw materials:

4-(4-methoxybenzylthio)phenylacetylene