3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Base Information

• Chemical Name: 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL
• CAS No.: 191155-81-4
• Molecular Formula: C10H11 F3 O
• Molecular Weight: 204.192
• Mol file: 191155-81-4.mol

Synonyms:3-(2-Trifluoromethylphenyl)propanol;3-[2-(Trifluoromethyl)phenyl]propan-1-ol

Chemical Property of 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Chemical Property:

• Vapor Pressure: 0.028mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 235.271°C at 760 mmHg
• Flash Point: 104.09°C
• PSA: 20.23000
• Density: 1.203g/cm³
• LogP: 2.63030

Purity/Quality:

97% ^*data from raw suppliers

2-(Trifluoromethyl)benzenepropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Trifluoromethyl)benzenepropanol is used to prepare tert-Bu O-tosyloxy hydroxyphenylpropylcarbamates and their dearomatizing spirocyclization and aryl amination reactions.

Technology Process of 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

There total 3 articles about 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

3-(2-(trifluoromethyl)phenyl)propanoic acid ethyl ester (191155-80-3) → 3-(2-(trifluoromethyl)phenyl)propan-1-ol (191155-81-4)

Guidance literature:

Reference yield: 93.0%

3-(2-(trifluoromethyl)phenyl)propanoic acid (94022-99-8) → 3-(2-(trifluoromethyl)phenyl)propan-1-ol (191155-81-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at -78 - 0 ℃; for 2h; Inert atmosphere;

Reference yield:

methyl 3-(2-(trifluoromethyl)phenyl)propanoate → 3-(2-(trifluoromethyl)phenyl)propan-1-ol (191155-81-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; Reflux;

DOI:10.3390/biom10091319

upstream raw materials:

3-(2-(trifluoromethyl)phenyl)propanoic acid ethyl ester

3-(2-(trifluoromethyl)phenyl)propanoic acid

Downstream raw materials:

3-(2-(trifluoromethyl)phenyl)propanal

1-(3-bromopropyl)-2-trifluoromethylbenzene

3-<2'-(trifluoromethyl)phenyl>-2-propenal