(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

Base Information

Chemical Name:(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one
CAS No.:925211-40-1
Molecular Formula:C₁₉H₁₉NO₄
Molecular Weight:328.34
Hs Code.:

Synonyms:(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

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Chemical Property of (3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

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Technology Process of (3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

There total 5 articles about (3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (rac)-cis-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

: 925211-40-1
(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

: C₁₇H₁₄⁽²⁾H₃NO₃

Guidance literature:: With Lipase PS Amano; In acetonitrile; for 168h; pH=7.2;
DOI:10.1021/ja0656604

Reference yield:

: C₁₅H₁₂⁽²⁾H₃NO

: 925211-40-1
(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3.7 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 50 percent / lipase PS Amano / acetonitrile / 168 h / pH 7.2

With Lipase PS Amano; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja0656604

Reference yield:

: 19215-16-8
p-trideuteromethylbenzoic acid

: 925211-40-1
(3R,4S)-1-(p-methoxyphenyl)-3-acetoxy-4-(p-trideuteriomethylphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 5 h / -20 - 20 °C

2: 94 percent / pyridinium chlorochromate / CH₂Cl₂ / 0.67 h / 0 °C

3: MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

4: 3.7 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

5: 50 percent / lipase PS Amano / acetonitrile / 168 h / pH 7.2

With lithium aluminium tetrahydride; Lipase PS Amano; magnesium sulfate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja0656604