(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

Base Information

Chemical Name:(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane
CAS No.:318261-76-6
Molecular Formula:C₁₈H₂₇IO₄Si
Molecular Weight:462.4
Hs Code.:

Synonyms:(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

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Chemical Property of (3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

Chemical Property:

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Technology Process of (3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

There total 4 articles about (3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-trimethylsilanylethynyl-phenyl)-pyrrolidin-1-yl-diazene

: 318261-76-6
(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

Guidance literature:: With methyl iodide; at 110 ℃; for 12h;
DOI:10.1021/ja002129e

Reference yield:

: 318261-40-4
(3,5-dibromo-phenyl)-pyrrolidin-1-yl-diazene

: 318261-76-6
(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; B(OMe)3 / diethyl ether / 2 h

1.2: CH₃CO₃H / diethyl ether / 1 h / 0 °C

2.1: DEAD; PPh₃ / tetrahydrofuran

3.1: 80 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

4.1: 76 percent / CH₃I / 12 h / 110 °C

With copper(l) iodide; n-butyllithium; Trimethyl borate; triethylamine; triphenylphosphine; diethylazodicarboxylate; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; diethyl ether; 2.1: Mitsunobu coupling / 3.1: Sonogashira coupling;
DOI:10.1021/ja002129e

Reference yield:

: 3-bromo-5-(pyrrolidin-1-ylazo)-phenol

: 318261-76-6
(3-iodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-phenylethynyl)-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: DEAD; PPh₃ / tetrahydrofuran

2: 80 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 18 h / 80 °C

3: 76 percent / CH₃I / 12 h / 110 °C

With copper(l) iodide; triethylamine; triphenylphosphine; diethylazodicarboxylate; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1: Mitsunobu coupling / 2: Sonogashira coupling;
DOI:10.1021/ja002129e